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Case Study: Safety & Effectiveness of Microneedling in Improving signs of Ageing skin


Abstract from Report published by Glynis Ablon, MD, FAAD on the JCAD or the Journal of Clinical and Aesthetic Dermatology, Aug 2018. [Source]. The purpose of this study was to evaluate the efficacy and safety of an automated microneedling device (Exceed, Amiea Med, MT.DERM GmbH, Berlin, Germany) when used for the rejuvenation of facial skin, as well as to generate data for an FDA 510K submission for the device.


Forty-eight subjects aged 35 to 75 years with signs of facial skin ageing were recruited. After consenting and satisfying inclusion criteria, each subject underwent four microneedling sessions 30 days apart. Subjects were assessed at baseline and at 30, 60, 90, and 150 days after the first treatment.


Wrinkles were assessed using the Lemperle Grading Scale. Skin laxity and texture were assessed using a modified Alexiades-Armenakas Grading Scale. Digital fringe projection technology (PRIMOS) was used to determine skin topography of the periorbital and mesolabial areas.


Mean improvements in global wrinkle score (mean of nine facial area grades), skin laxity, and skin texture at Day 150, compared to baseline were 1.23 (99% confidence interval [CI]: 1.11, 1.34), 1.09 (99% CI: 0.93, 1.26), and 1.54 (99% CI: 1.33, 1.75), respectively. Statistically significant mean improvements in these three measures were also observed at Day 90. Improvements in wrinkle grading and skin texture were confirmed by the PRIMOS profilometry. The treatment was well tolerated with minimal pain, discomfort, and downtime. Side effects were minor and easily managed. 


This study demonstrates that four microneedling treatments of facial skin, spaced four weeks apart, significantly improve lines, wrinkles, skin laxity and skin texture, 90 and 150 days after the first treatment. The treatment was well tolerated with minimal pain, discomfort, and downtime. Side effects were minor and easily managed compared to other invasive technologies, such as laser ablation and radiofrequency.


About Microneedling

As the demand for effective, less invasive aesthetic procedures increases, so does the quest for successful solutions. Patients often request therapies to rejuvenate photo-damaged skin, lighten abnormal pigmentation, smooth textural problems, diminish rhytides, and improve skin laxity. This search for younger-looking skin has generated many different cosmetic techniques with varying degrees of invasiveness and efficacy, such as carbon dioxide laser resurfacing, deep chemical peels, and fractionated laser technology.1–4 Predominantly, these techniques work by damaging or causing the destruction of the epidermis, which leads to changes in the dermis that consequently initiate an inflammatory response, resulting in the production of new collagen and skin.5,6 There is, however, a cost to such invasive procedures. Typically, ablative techniques produce thicker bundles of scar collagen rather than the lattice network of collagen found in normal skin. Additionally, ablative procedures can cause the skin to become more sensitive to photo-damage and more susceptible to post-procedural complications. 

Microneedling, also known as percutaneous collagen induction (PCI), is a minimally invasive technique that was first described as a principle by Orentreich and Orentreich8 whereby subcutaneous subcision surgery stimulates collagen beneath retracted scars and wrinkles. Fernandes used a similar technique of inserting a 15-gauge needle into the skin under the wrinkles. The technique by Fernandes was followed by the development of the dermal roller.9 A dermal roller is a sterile plastic cylinder with stainless steel needles protruding 1 to 3mm from the surface of the cylinder. The dermal roller is rolled vigorously over the skin to create numerous needle pricks, which lead to thousands of microscopic wounds in the dermis, initiating the natural post-traumatic inflammatory response (i.e., the release of growth factors and the formation of collagen and elastin). 

​​PCI treatment preserves the epidermis while stimulating collagen deposition, thereby reducing the risk of post-treatment complications and patient downtime. Today, PCI treatment can be performed in-office, and patients can resume normal activity the next day.


Conditions that respond to microneedling

​In addition to age-related skin conditions (e.g., wrinkles, laxity), there is a growing list of dermatological conditions that respond to PCI therapy, including acne scars, dyspigmentation, alopecia, and hyperhidrosis, and use of PCI in transdermal drug delivery have also been reported.

Microneedling device used for case study

​The microneedling device used in this study primarily consists of a handpiece, safety needle cartridge, and control unit. The handpiece contains the motor that moves the needles of the safety needle cartridge and a needle depth gauge that allows the user to control the depth of needle incision from 0 to 1.5mm. The control unit allows the user to adjust the frequency of the needle stroke from 100 to 150hz. The safety needle cartridge contains six sterile, single-use, stainless steel microneedles (maximum 1.5mm length, 0.35mm gauge)


Microneedling Treatment protocol

Each subject underwent four microneedling sessions that were 30 days apart. After cleansing the face, a topical anesthetic (LMX 4, Eloquest Healthcare, Ferndale, Michigan) was applied to the entire face and jawline. After 30 minutes, the topical anesthetic was removed by wiping the skin with a cotton pad soaked in 70% isopropyl alcohol, and the skin was allowed to dry. A liberal quantity of Sterile Clear Image singles gel (NEXT Medical Products Company, Branchburg, New Jersey) was applied to the subject’s face to assist the movement of the needle cartridge over the skin, and the needle cartridge was then moved in circular motion across the face. The following needle depths were used to achieve pinpoint bleeding:

  • forehead 0.7 to 1.0mm;
  • cheek 0.9 to 1.5mm;
  • eye area 0.5 to 0.8mm;
  • chin 0.9 to 1.3mm;
  • glabella and jawline 0.7 to 1.3mm;
  • upper lip 0.7 to 1.0mm.

After treatment, the skin was cleansed with warm water and sterile gauze. Subjects were provided instructions for post-skin care, including the use of moisturiser and sun block.

Results of case study

Forty-eight subjects were enrolled in the study, all of whom completed treatment and assessment visits. No subjects withdrew from the study due to issues related to study protocol or AEs. Data from all subjects were included for analysis.

The mean age of the subjects was 55.1 years (range 39–67 years), and the subjects were predominantly female. Fitzpatrick phototypes ranged from I to V with a mean of 2.2. Baseline scores and range for wrinkles, skin laxity, and skin texture were 3.2 (2.2–4), 2.8 (2–3.5), and 2.7 (1.5–3.5), respectively.

The TABLE below shows the mean wrinkle grade for each of the nine assessment areas at baseline and Days 90 and 150, together with summarised changes at follow-up.


At Day 90, four facial areas had improved by at least one grade—glabella frown lines, periorbital lines, cheek folds, and upper lip lines. The mean improvement in global score was 0.93 (99% CI: 0.81, 1.06).

At Day 150, six of the nine facial areas had improved by at least one grade—horizontal forehead lines, glabella frown lines, periorbital lines, cheek folds, upper lip lines, and labiomental crease. The mean improvement in global score was 1.23 (99% CI: 1.11, 1.34) with p=2.5×106 (i.e., highly significant).

Mean values for line roughness and surface roughness for the periorbital regions and mesolabial regions are shown in Tables 2 and ​and3.3. At both Day 90 and Day 150 assessment points, mean improvements were observed for all roughness parameters (R# and S#) in both the periorbital and mesolabial regions. Table 4 shows mean skin laxity and skin texture grades at baseline and Days 90 and 150 and mean changes at follow-up. Mean improvement in skin laxity was 0.82 (99% CI: 0.69, 0.95) at Day 90 and 1.09 (99% CI: 0.93, 1.26) at Day 150. A significance test of the mean improvement at Day 150 against 1.0 gave p=0.07, exceeding the study significance level of 0.0083. Mean improvement in skin texture was 1.33 (99% CI: 1.16, 1.51) at Day 90 and 1.54 (99% CI: 1.33, 1.75) at Day 150. Both of these mean values were significantly greater than 1, with p=7.0×106 and p=1.3×108, respectively.


Conclusion of microneedling case study

Microneedling, or PCI, is a relatively simple in-office procedure that appears to be effective in the treatment of facial wrinkles, skin laxity, and skin texture. Past studies using the technique have lacked sufficient numbers of test subjects. Our study, presented here, evaluated a microneedling system for the treatment of facial ageing among a suitably sized sample of patients.

During the procedure, microscopic wounds created in the papillary dermis by the microneedles being driven into the skin result in the normal chemical cascade that follows trauma. This consists of an inflammatory stage, with its subsequent release of cellular growth factors, followed by the proliferative stage, and ultimately the remodeling stage, with the stimulation of neocollagenesis and formation of a tighter collagen matrix.

Microneedling for Scalp

In out study, the subjects demonstrated improvement in facial wrinkles and skin texture at the end of the treatment sequence on Day 90, but with a maximal (statistically significant) effect seen in all three parameters at Day 150. This improvement in facial wrinkles demonstrates the cumulative effect of percutaneous collagen induction and ongoing dermal collagen remodeling, and it confirms previous observations described in the literature.9,10 Improvements in skin laxity are predominantly the result of Collagen III being converted to Collagen I, with the subsequent tightening of the skin. Since this process takes as long as 12 months to complete, it is not surprising that statistically significant results were not seen until Day 150 of our study. Future studies would benefit from an interim follow-up at Day 120 and an extended follow-up period of 6 to 12 months to fully appreciate the potential of this technology. Conversely, statistically significant improvements in skin texture were demonstrated by the end of the treatment course at Day 90. With conversion of Collagen III to Collagen I and subsequent skin tightening, one would expect epidermal remodeling to take place and be more measurable in the earlier stages of PCI treatment, as opposed to the later stages.

Results of wrinkle grading and skin texture improvements were confirmed by 3D profilometry. As expected, the improvement seen in the common roughness indices appeared greater than observer grading measurements. This reflects previously published data by Friedman and Fujiwara. However, the results validate the value and effectiveness of 3D profilometry in providing higher resolution of skin topography than clinical assessment alone, supporting the use of 3D profilometry in measuring improvements that cannot necessarily be identified by a trained rater.

​In this study, we demonstrated that four microneedling treatments of facial skin, spaced four weeks apart, produce noticeable improvements in lines and wrinkles, skin laxity, and skin texture at Days 90 and 150 following the first treatment.

Gold RF Microneedling Facial by Wellaholic

Gold RF Microneedling is a revolutionary skin treatment that delivers dramatic anti-ageing results by combining fractional radiofrequency (RF) with microneedling to effectively treat acneacne scarpigmentation, stretch marks & enlarged pores. Gold RF Microneedling can also lift saggy skin and revitalise dull and uneven skin tone.

What is Gold RF Microneedling Facial Treatment?

If you are looking for an effective method to clear your acne scars, wrinkles or pigmentation, or if you are looking to tighten saggy skin such as jowl lines and nasolabial folds without any invasive surgery, then Gold RF Microneedling is the right treatment for you. Gold RF Microneedling combines two scientifically-proven techniques, microneedling and fractional radiofrequency (RF) to treat a variety of skin conditions. 

  • Gold RF Microneedling uses up to 64 needles to penetrate the skin, releasing RF energy to trigger collagen and elastin production for the ultimate anti-ageing treatment for a clearer complexion and firmer skin.
  • Gold RF Microneedling is a safe, minimally invasive, and extremely effective aesthetic treatment for treating acne scars, pigmentation, fine lines and wrinkles.
  • Gold RF Microneedling has the ability to stimulate the growth of collagen and elastin using the combination of Microneedling with Radiofrequency, which is the key to new, youthful-looking skin.
  • Gold RF Microneedling has a dermatological treatment has seen extensive positive clinical results. This is an improvement over just doing a Microneedling or Radiofrequency treatment on its own.

Gold RF Microneedling combines radiofrequency with microneedling to stimulate tissue remodelling, thereby triggering the production of collagen.

Gold RF Microneedling Science

What are the Benefits of Gold RF Microneedling Facial?

Gold RF Microneedling has all the skin resurfacing benefits of traditional microneedling, but with the added technology of insulated needles that deliver RF energy to the skin, creating new microchannels linking your skin’s layers.

  • Gold RF Microneedling create tiny wounds in your skin to prompt your body to replace old skin cells with healthy new ones, the RF energy heats deep layers of your dermis to encourage collagen growth and tissue tightening, leading to visibly healthier skin that continues to improve over the following months.
  • Gold RF Microneedling leads to faster cell turnover and quicker results than traditional microneedling.
  • Gold RF Microneedling has a shorter recovery time as compared to traditional microneedling, laser resurfacing treatments and chemical peels. There is also less risk of hyperpigmentation.

Pricing of Facial Treatments by Wellaholic

Wellaholic believes in providing pricing transparency, and hence all our prices are published and updated on its website. Choose from a single-session plan or choose a multi-session plan for greater discounts. Wellaholic’s facial treatments are generally divided into the following categories: 

Wellaholic Services Comparison (1024 × 569px)

Please click on the menu below to see the pricing for the various facial treatments by Wellaholic. Wellaholic is well-known in the industry for our transparent pricing and no hard selling. In fact, Wellaholic is well-known for not only our transparent and cheap pricing but also without any hidden costs. All prices are nett and inclusive of GST, and are actual prices (i.e. not trial prices).

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