Clinical Evaluation of a Novel Blended Mode Diode Laser for Hair Removal

Wellaholic Research: Clinical Evaluation of a Novel Blended Mode Diode Laser for Hair Removal

TL:DR Summary

  • Innovative Blended Mode Lasers: Explore the effectiveness of 755/810 nm and 810/1064 nm blended mode diode lasers for hair removal.
  • Extensive Clinical Evaluation: Results from 100 patients across various clinics demonstrate significant hair reduction with these novel lasers.
  • High Efficacy in Hair Reduction: Average hair count reduction of 84% for 755/810 nm and 81% for 810/1064 nm handpieces.
  • Safe for Diverse Skin Types: Proven safe and effective for various skin types and hair characteristics, enhancing treatment versatility.
  • Optimized for Different Hair Colors: The combination of wavelengths allows for effective treatment across different hair colors and skin types.
  • Personalized and Effective Treatments: This novel approach offers more accurate and personalized hair removal, maximizing results while minimizing risks.


Introduction: Photoepilation by lasers is a popular procedure in aesthetic dermatology for removing unwanted body and facial hair. The use of the most appropriate laser wavelength is crucial as it affects treatment depth and melanin absorption. The three commonly used hair removal lasers are of specific wavelengths: 755 nm, 810 nm, and 1064 nm, each preferred certain types of skin and hair characteristics. The current evaluation reports the safety and efficacy of unique blended modes 755/810 nm and 810/1064 nm diode lasers for hair removal. 

Methods: Hair removal results from 50 patients treated with the 755/810 nm handpiece and 50 patients treated with the 810/1064 nm handpiece were gathered from a few clinics. 3 treatments on various body areas were conducted 6 weeks apart and patients were followed up with 6 months after the last treatment. Results were evaluated by baseline, follow-up photographs, and hair counts. 

Results: Treatment area photos demonstrated hair reduction in the treated body and facial areas. Average hair count reduction at 6 months follow-up was 84% for the 755/810 nm handpiece and 81% for the 810/1064 nm handpiece. No significant or unexpected adverse events were detected in any of the patients. 

Conclusions: The novel blended mode hair removal diode lasers are proven to be safe and effective for hair removal in facial and body areas for patients of various skin types and hair characteristics.

The image portrays the professional environment of Wellaholic’s Boyzilian hair removal service. It emphasizes the hygienic and comfortable atmosphere, with a focus on client privacy. The state-of-the-art equipment used for the procedure is also featured, demonstrating Wellaholic’s dedication to providing top-notch, pain-free hair removal solutions. The overall image communicates a strong sense of trust and quality, assuring potential customers of the exceptional service they can anticipate at Wellaholic.

1. Introduction

Laser hair removal treatment is based on the principle of selective photothermolysis. In this process, the absorbed optical energy is converted into heat, coagulating the hair follicle [1] . There are preferential wavelengths for melanin absorption. At three specific wavelengths (755 nm, 810 nm, and 1064 nm), absorption by melanin is greater than competitive absorption by oxyhemoglobin and water. These wavelengths correspond to three popular hair removal lasers: 755 nm alexandrite, 810 nm diode, and 1064 nm Nd:YAG lasers [2] .

Numerous published clinical studies have demonstrated the safety and efficacy of different lasers at various wavelengths for hair removal [1] [3] .

Based on clinical evidence, hair removal diode lasers of 810 nm are considered as the universal hair removal for all skin types, and these lasers are commonly used in the market [1] [2] [3] . Light color or fine hair may be resistant to the treatment due to scarcity of pigmentation in the hair shaft, whereas treatment of dark skin type patients is difficult due to skin melanin absorption [1] . Light color and fine hair respond better to 755 nm, while a wavelength of 1064 nm is more suitable for dark skin [2] .

Recently new diode lasers of 755 nm and 1064 nm were developed to enable suitable diode laser treatments for a wide variety of skin and hair types [4] [5] [6] .

This manuscript describes the evaluation of a newly developed device with two different handpieces generating optical energy from diode bars at 755 and 810 nm simultaneously and at 810 and 1064 nm simultaneously. The novel blended wavelength handpieces are applied to the skin for selective hair removal for a variety of hair and skin types.

This study presents results of a multicenter evaluation of the blended wavelength 755/810 nm and 810/1064 nm lasers for hair removal.

2. Materials and Methods

The Device

The InMode Triton/DiolazeXL device (InMode MD Ltd., Israel) is designed to deliver optical energy to the skin via a pre-cooled sapphire block. Good optical contact between the sapphire block and the skin is achieved by using water-based gel. The device provides individual adjustment of light fluence and pulse duration to achieve maximum efficiency and safety for each patient. The handpiece has integrated skin cooling to enhance safety and comfort of the treatment.

The device is shown in Figure 1.

The diode laser handpieces are available in 3 wavelength configurations:

・ Mix of 755 nm/810 nm and a mix of 810 nm/1064 nm. 810 nm alone is also available as the most commonly used wavelength, but it is not the subject of this study.

・ Each of the handpieces are comprised of 20 diode laser bars stacked vertically. With the blended modes the corresponding diode bars are alternated and the two wavelengths of 755/810 or 810/1064 are emitted simultaneously through a chilled sapphire light guide.

A schematic representation of the alternating diode bars is illustrated in Figure 2.

The diode laser produces up to 3000 W peak optical power.

The sapphire light guide is located at the front of the handpiece and delivers the laser beam energy to the treated tissue, while cooling the skin. The sapphire block is surrounded by a chilled gold-plated metal frame. This structure provides increased cooling to a temperature of about 7˚C on the treatment spot and a few millimeters around it. The handpiece cooling flow is demonstrated in Figure 3. The arrow indicates the tip progress direction on the skin. One part of the metal frame is responsible for pre-cooling, the sapphire light guide is responsible for the cooling stage and the other part of the metal frame is responsible for post-cooling during handpiece progression.

The dimensions of the sapphire light guide are 11 mm × 27.5 mm.

A temperature sensor is located on the enclosure of the sapphire cooler and measures the temperature of the tissue cooler to ensure stable sapphire temperature.

Evaluation Design

The objectives of this multicenter evaluation were to gather safety and efficacy hair removal data of the newly developed diode laser blended modes 755/810 nm and 810/1064 nm handpieces.

Results from 50 subjects treated with the 755/810 nm handpiece and 50 subjects who were treated with the 810/1064 nm handpiece were accumulated from a few clinics in the USA, Canada, France, and Israel during 2018.

Subjects underwent 3 treatment sessions 6 weeks apart and were followed up with 6 months post their last treatment.

Female and male subjects of Caucasian, Hispanic, Asian, and Afro-American backgrounds were treated on different areas such as the legs, underarms, bikini, chest, back and face.

The study efficacy was assessed by average hair reduction at the 6 month follow-up visit compared to the baseline count. Hair counts were performed on photographs taken from the subjects’ treatment areas. Subjects consented to use of their photographs.

Safety of the device was evaluated by assessing the incidence, severity and persistence of adverse events, if any occurred during the study period.


Photos of the treatment areas were taken at baseline and at the 6 month follow-up visit in a reproducible manner. The hair was trimmed to 1 – 3 mm length and the area before trimming as well as the trimmed area was photographed. Hair counts were performed by marking visible hairs on photographs of the subjects’ treatment area. Figure 4 demonstrates counting examples.

3. Results

Hair removal results from 50 subjects treated with the 755/810 nm laser and 50 subjects treated with the 810/1064 nm laser were included in the study. All subjects had completed all treatment and follow-up regimen.

Results of Hair Removal Using the 755/810 nm Handpiece

44 female subjects and 6 male subjects, who requested hair removal treatments, were treated with the 755/810 nm handpiece. The mean subject age was 25.4 with minimum and maximum age of 19 and 36, correspondingly. Subjects had the following Fitzpatrick skin types: type II (66%) and type III (34%).

Subjects were treated on various treatment areas for hair removal with the 755/810 nm blended mode hand piece including underarm, bikini, legs, face, men’s back, and chest.

Analysis of hair count change from baseline to the 6 month follow-up (Table 1) resulted in a weighted average hair count reduction of 84% (range of 75% – 88%).

Representative photos of various areas treated with the 755/810 nm diode laser handpiece taken at baseline and at 6 month follow-up time points are presented below in Figures 5-7.

Results of Hair Removal Using the 810/1064 nm Handpiece

50 female subjects, who were interested in hair removal treatments, were treated with the 810/1064 nm handpiece. The mean subject age was 24 with a range of 19 – 36. Subjects had the following Fitzpatrick skin types: type IV (37.5%), type V (41.5%) and type VI (21%).

Subjects were treated on various treatment areas for hair removal with the 810/1064 nm blended mode handpiece, including underarm, bikini, legs, and face.

Analysis of hair count change from baseline to the 6 month follow-up resulted in an average weighted hair count reduction of 81% (range of 70% – 84%). (Table 2).

Treatment areaNo.Average % reduction
Table 1. Weighted average hair count reduction according to different treatment areas.
Figure 5. Arm treated with 755/810 handpiece at baseline (left) and at 6 months after last treatment (right).

Figure 6. Underarm treated with 755/810 hand piece at baseline (left) and at 6 months after last treatment (right).

Representative photos of various areas treated with the 810/1064 nm diode laser handpiece taken at baseline and at 6 months follow-up time points are presented below in Figures 8-10.

Figure 7. Underarm treated with 755/810 hand piece at baseline (left) and at 6 months after last treatment (right).

Treatment areaNo.Average % reduction
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4. Discussion

The choice of an optimal laser for the individual patient is critical for treatment success and safety. One should take into consideration the patient’s skin and hair types to match laser wavelength that will reflect melanin absorption and penetration depth.

The wavelength range of 650 to 1300 nm is considered generally suitable for typical depth of hair from 1 mm to 3 mm. The best penetration depth is around 1060 nm corresponding to the Nd:YAG laser, but this wavelength absorption in hair melanin is relatively low and efficacy of treatment is not very high. The maximal efficacy is around 650 – 700 nm but penetration depth is limited at this wavelength.

A wavelength of 755 nm is considered very effective for light skin treatment [4] while the 1064 nm Nd:YAG laser became popular for hair removal on dark skin patients [5] [6] .

One of the compromises between these two ranges is the use of an 810 nm diode [7] [8] [9] [10] [11] which has better penetration depth than 755 nm and much higher absorption coefficient of melanin than the Nd:YAG laser. Sometimes better tuning of the wavelength is optimal, especially for darker skin and non-black hairs.

For dark skin it would be a logical step to use a wavelength between 810 nm and 1064 nm, but the peak of light absorption by water in this range makes these wavelengths less effective for treatment. In addition, not all wavelengths are available in the market because of technological limitations.

One of the solutions is to use a combination of two wavelengths, which are already well-known and clinically proven for laser hair removal treatment.

The use of combination 810 nm and 1064 nm would improve penetration depth and safety for darker skin while maintaining relatively high efficacy of treatment.

Combination of 755 nm and 810 nm would allow optimization of treatment for different hair colors.

Because all these wavelengths are recognized as safe and effective for hair removal the combination of the wavelengths does not seem to raise any safety concerns and enables efficacy optimization.

The novel diode laser Triton/DiolazeXL with the blended mode of wavelengths, 755/810 nm and 810/1064 nm, enables a wide range of penetration depths and hair melanin absorption. Figure 11 illustrates the unique penetration of the two blended mode lasers.

Clinical experience supports the safety and efficacy of both handpieces for hair removal on light and dark skin in various body and facial areas with a range of hair types.

The current evaluation demonstrated treatment results from female and male subjects who underwent 3 treatment sessions 6 weeks apart and were followed up with 6 months following their last treatment. As expected, due to better absorption in melanin of the lower wavelength, subjects treated with 755/810 nm hand piece displayed slightly better hair reduction results (average reduction of 84%) than those treated with 810/1064 nm handpiece (average reduction of 81%). When comparing different treatment areas, underarms presented the best hair reduction, as expected from relatively lighter skin and coarser, darker hair in these areas. The same applies to bikini areas, but to a slightly lesser degree. The legs usually have finer hair than underarm and bikini, and exhibited less hair reduction, as well as deeper hair on men’s back and chest. The lowest percent of hair reduction was expressed on the face due to its very fine hair with a limited amount of melanin. All the above is applicable to both handpieces, 755/810 nm and 810/1064 nm.

No unexpected adverse events were reported in this study.

The clinical data presented here demonstrate that the unique blended mode of wavelengths, 755/810 nm and 810/1064 nm, has proven to be safe and effective for hair removal on light and dark skin.

The novel combination approach enables more accurate and personalized treatment, thus maximizing hair removal results while minimizing treatment risks. More studies are planned to further substantiate the potential clinical contribution of the newly developed blended wavelengths concept.


With over 8 years of experience in the aesthetics industry, I am passionate about enhancing beauty and wellness through innovative, science-based approaches. As the Aesthetic Director at Wellaholic, I am committed to delivering exceptional services that are tailored to each client's unique needs. My expertise spans across advanced skincare treatments, body sculpting, hair removal services, and nutritional supplements, all aimed at helping clients achieve their personal best.

Serene Chiam, Aesthetic Director

Serene Chiam is the Aesthetic Director at Wellaholic, a well-known aesthetic chain in Singapore. She has more than ten years of experience in the aesthetics industry. With a Bachelor of Health Science (Aesthetics) and CIDESCO certifications, she expertly combines scientific knowledge with practical skills. Serene is known for her personalized approach to beauty, ensuring each Wellaholic client’s journey is unique and transformative. Her significant contributions have been pivotal in establishing Wellaholic’s reputation for excellence in aesthetic wellness.

Contact Serene at


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Wellaholic Research: A Clinical Evaluation of the Novel Blended Mode Diode Laser for Effective Hair Removal

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